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Zidovudine Other Interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential ificance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.
Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines.
Make sure you store the medicine in a safe and secure place to prevent others from getting it. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the Opuate web opiatee for locations. Here is the link to the FDA safe disposal of medicines website:www.
Precautions It is very important that your doctor check your progress while you are taking this medicine, especially within the ittch 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Blood and urine tests may uow needed to check for unwanted effects. It is against the law and dangerous for anyone else to use your medicine. Keep your unused medicine in a safe and secure place. People who are addicted to drugs might want to steal it. This medicine will add to the effects of alcohol and other CNS depressants medicines that can make you drowsy or less alert. Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.
Also, there may be a greater risk of liver damage if you drink three or more opiage beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.
This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
Using these medicine together may cause serious unwanted effects. This medicine may cause sleep-related breathing problems eg, sleep apnea, sleep-related hypoxemia. Your doctor may decrease your dose if you have sleep apnea stop breathing for short periods during sleep while using this medicine. Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or tto.
This medicine may make you dizzy, drowsy, or lightheaded.
Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Serious skin reactions can occur with this medicine. Check with opiatee doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet.
Be sure to follow the directions carefully, because continuing constipation can lead to opkate serious problems.
If you have been using this medicine regularly for several weeks or longer, do not change your dose or suddenly stop using it without checking with your doctor. Your doctor may want you to gradually reduce the amount you opiste using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as stomach cramps, anxiety, fever, irritability, nausea, restlessness, runny nose, sweating, tremors, or trouble with sleeping.
Jow this medicine while you are pregnant may cause serious unwanted effects, including neonatal withdrawal syndrome in your newborn baby.
Tell your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine. For nursing mothers: Talk to your doctor if you have any questions about taking oxycodone or about how this medicine may affect your baby. Call your doctor if you become extremely tired and have difficulty caring for your baby.
Your baby should generally nurse every 2 to 3 hours and should not sleep for more than 4 hours at a time. Check with your doctor or hospital emergency room immediately if your baby shows s of increased sleepiness more than usualdifficulty breastfeeding, difficulty breathing, or limpness. These may be symptoms of an overdose and need immediate medical attention.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The of some tests may be affected by this medicine. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome.
Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.
Using too much of this medicine may reduce infertility unable to have children. Talk with your doctor before using this medicine if you plan to have children.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements. Side Effects Along with its needed effects, a medicine may cause some unwanted effects. They may help to reduce opioid requirements and associated side effects.
If the patient is receiving other medication that may cause sedation e. Palliative care Regular monitoring such as blood pressure and temperature, pulse and respiratory rate are not as essential in palliative care patients- can be negotiated with ward staff and families.
Please opiare the patient hourly. Pain and symptom management is essential and must be carried out hourly including administration of site check. Doses are calculated on a 24 hr period rather than hourly infusions rates. If there are concerns about opioid toxicity we strongly recommend assessment of pupils and the use of naloxone should be considered cautiously and in consultation with VPPCP given it may exacerbate a pain crisis during end of life care.
Infusions may be delivered subcutaneously rather than intravenously. Please refer to the Subcutaneous catheter devices management CPG. Butterfly Pain assessment is performed using the mPAT. The mPAT is a valid, reliable, clinically useful and feasible tool. See: Neonatal Pain Assessment CPG Preparation of opioids is of a different strength as per unit policy, infusions should be changed prior to discharge from Butterfly to RCH inpatient wards The hos of opioid analgesics may be increased and renal drug excretion may be prolonged due to immature renal function.
The only exception for this would be on agreement with neonatal consultant when oral opioids are weaning and have reached minimal dosing.
Patients receiving IV opioid boluses that are also on continuous cardiorespiratory monitoring in the intensive care environment with nursing are not required to document following the bolus as per Table 4.
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